Pharmacological activation of STAT1-GSDME pyroptotic circuitry reinforces epigenetic immunotherapy for hepatocellular carcinomaYalin Tu, Haoran Wu, Chengpeng Zhong, Yan Liu, Zhewen Xiong, Siyun Chen, Jing Wang, Patrick Pak-Chun Wong, Weiqin Yang, Zhixian Liang, Jiahuan Lu, Shufen Chen, Lingyun Zhang, Yu Feng, Willis Wai-Yiu Si-TouSee the full list of authors
1 November 2024
IQGAP3 signalling mediates intratumoral functional heterogeneity to enhance malignant growthMitsuhiro Shimura, Junichi Matsuo, ShuChin Pang, Nawaphat Jangphattananont, Aashiq Hussain, Muhammad Bakhait Rahmat, Jung-Won Lee, Daisuke Douchi, Jasmine Jie Lin Tong, Khine Myint, Supriya Srivastava, Ming Teh, Vivien Koh, Wei Peng Yong, Jimmy Bok Yan SoSee the full list of authors
22 October 2024
Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM studyVictoria Wilkinson-Smith, Mark Scott, Alex Menys, Lukasz Wiklendt, Luca Marciani, David Atkinson, Stefano Sansone, Ausra Zdanaviciene, Carol Coupland, Charles H Knowles, Philip Dinning, Stuart A Taylor, Penny Gowland, Caroline Louise Hoad, Maura CorsettiSee the full list of authors
22 October 2024
Spatial single-cell profiling and neighbourhood analysis reveal the determinants of immune architecture connected to checkpoint inhibitor therapy outcome in hepatocellular carcinomaHenrike Salié, Lara Wischer, Antonio D’Alessio, Ira Godbole, Yuan Suo, Patricia Otto-Mora, Juergen Beck, Olaf Neumann, Albrecht Stenzinger, Peter Schirmacher, Claudia A M Fulgenzi, Andreas Blaumeiser, Melanie Boerries, Natascha Roehlen, Michael SchultheißSee the full list of authors
30 September 2024
Nuclear translocation of plasma membrane protein ADCY7 potentiates T cell-mediated antitumour immunity in HCCJianan Chen, Youhai Jiang, Minghui Hou, Chunliang Liu, Erdong Liu, Yali Zong, Xiang Wang, Zhengyuan Meng, Mingye Gu, Yu Su, Hongyang Wang, Jing Fu
30 September 2024
Correction: Differential inflammasome activation predisposes to acute-on-chronic liver failure in human and experimental cirrhosis with and without previous decompensationBMJ Publishing Group Ltd and British Society of Gastroenterology
7 October 2024
Untargeted faecal metabolomics for the discovery of biomarkers and treatment targets for inflammatory bowel diseasesArnau Vich Vila, Jingwan Zhang, Moting Liu, Klaas Nico Faber, Rinse K Weersma
13 July 2024
Submucosal steroid pre-injection strategy to prevent oesophageal stricture after circumferential endoscopic submucosal dissectionKe Zhan, Pengfei Wang, Wei-hui Liu, Yang Bai, Daorong Chen, Ling Sun, Min Qiao, Jianhua Dai, Xusheng Nie, Xin Yang
3 August 2024
What defines a healthy gut microbiome?Matthias Van Hul, Patrice D Cani, Camille Petitfils, Willem M De Vos, Herbert Tilg, Emad M El-Omar
25 September 2024
Pancreatic STAT5 activation promotes Kras-induced and inflammation-induced acinar-to-ductal metaplasia and pancreatic cancerYuli Lin, Shaofeng Pu, Jun Wang, Yaqi Wan, Zhihao Wu, Yangyang Guo, Wenxue Feng, Ying Ying, Shuai Ma, Xiang Jun Meng, Wenquan Wang, Liang Liu, Qing Xia, Xuguang Yang
1 July 2024