Gut,
a leading international journal from BMJ and BSG, publishes cutting-edge gastroenterology and hepatology research and reviews
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Hepatology:
Circulating tumour DNA in patients with hepatocellular carcinoma across tumour stages and treatments25 July 2024
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Recent advances in clinical practice:
Updates to the modern diagnosis of GERD: Lyon consensus 2.05 January 2024
Guideline:
British Society of Gastroenterology guidelines on sedation in gastrointestinal endoscopy5 January 2024
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Podcasts
Featured Video
PNPLA3 fatty liver allele was fixed in Neanderthals and segregates neutrally in humans
Conclusion: Archaic human individuals exclusively carried a fixed PNPLA3 allele associated with fatty liver, whereas allele frequencies in modern human populations are variable even in the oldest samples. Our observation might underscore the advantage of fat storage in cold climate and particularly for Neanderthal under ice age conditions. The absent signals of natural selection during modern human history does not support the thrifty gene hypothesis in case of PNPLA3 p.I148M.
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